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- Analytical Chemistry
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- Hit Identification
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- CDH (Target Gene Fragmentation)
- Cryogenic Electron Microscopy (Cryo-EM)
- Differential Scanning Fluorimetry (DSF) and nanoDSF Services
- Direct-to-Biology (D2B)
- eProtein Discovery
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- Fragment Based Drug Discovery (FBDD)
- FragmentBuilder
- Grating-Coupled Interferometry
- High Throughput Screening
- Isothermal Titration Calorimetry (ITC)
- LeadBuilder
- PoLiPa (Membrane Protein Solubilisation)
- Spectral Shift and MST Services
- Structure Based Drug Design (SBDD)
- Surface Plasmon Resonance (SPR)
- X-ray Crystallography
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Biophysical Assays
Breaking boundaries with the latest biophysical methodologies
We deploy state-of-the art biophysical methods to provide exquisite insight on interactions of compounds with biological targets.
At Domainex, we ensure we stay at the cutting edge of biophysics by employing the latest techniques such as Grating Coupled Interferometry (GCI), Spectral Shift, Isothermal Titration Calorimetry (ITC) and Differential Scanning Fluorimetry (DSF). Using state-of-the art instrumentation allows us to gain crucial insights into challenging drug discovery programmes for our clients. We can elucidate ligand-target engagement by understanding the structural basis of drug binding, as well as measuring affinities (dissociation constants), kinetics (kon and koff) and energetics (enthalpic and entropic contributions to drug binding). Domainex is one of the leading experts in generation and interpretation of this data, and we use this knowledge on a routine basis to support both the Hit Identification and Lead Characterisation phases of your drug research projects.
Biophysical Methodologies
We are able to deploy a suite of high-end technology platforms on your programmes:
- Grating-Coupled Interferometry (GCI) an analogous technique to Surface Plasmon Resonance (SPR)
- Spectral Shift, Temperature Related Intensity Change (TRIC) and MicroScale Thermophoresis (MST)
- Isothermal Titration Calorimetry (ITC)
- Differential Scanning Fluorimetry (DSF) and nanoDSF
- Mass photometry
- Dynamic Light Scattering (DLS)
- NMR STD & WaterLOGSY
- X-ray crystallography
- Cryo-EM
We are adept at deploying these techniques to inform your research project in an efficient and insightful manner. In addition to this, the techniques of GCI and spectral shift are much newer and Domainex has developed unique know-how that has made us widely recognised as a world-leader in its use.
GCI and Spectral Shift Services
As a Spectral Shift and GCI service provider, Domainex employs state-of-the-art instruments from NanoTemper and Malvern Panalytical. These techniques are at the core of our fragment screening platform FragmentBuilder. We also use these instruments for screening and characterising compounds arising from our LeadBuilder virtual screens and subsequently through hit-to-lead and lead optimisation campaigns.
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