Webinar | Tackling the challenges of membrane protein purification: Enabling drug discovery programs

Presenters: Jim Reid, Senior Principal Scientist – Protein Biology and Nathan Zaccai, Associate Principal Scientist

In the second of our Drug Discovery webinar series, we discuss the challenges of membrane protein purification. The series is hosted by One Nucleus.

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The expression and purification of membrane proteins suitable for drug discovery programs often presents a challenge. During this webinar, we present and discuss our capabilities to produce assay-ready and structural biology grade membrane proteins in both detergent and polymer nanodiscs. Case studies include a small molecule GPCR fragment screen using biophysical methods and a 3.0 Å, agonist bound structure of an ion channel using Cryo-EM.

Agenda:

• Introduction from One Nucleus and Domainex
• Presentation from Jim Reid, Senior Principal Scientist – Protein Biology and Nathan Zaccai, Associate Principal Scientist, Domainex
• Q&A and Close