Webinar | The reemergence of covalent compounds: Domainex’s approach to covalent fragment screening

Presenters: Andrew Ratcliffe, Head of Chemistry and Scott Martin, Head of the Bioanalytical Sciences Department

In the fourth of our Drug Discovery webinar series, we will be discussing covalent fragment screening and its reemerging promise in drug discovery. The series is hosted by One Nucleus.

14.00-15.00 BST | Monday 9th December 2024 | Online

Covalent inhibitors have reemerged as a hot topic in drug discovery research. During this webinar, we will discuss our approach to identifying high quality covalent fragment hits. This will include curation of our diverse covalent fragment library, covalent fragment screening by intact mass spectrometry, assessment of warhead reactivity with glutathione (GSH), confirmation of the fragment binding site by peptide mapping and generation of Ki/kinact values by LC-MS.

Agenda:
14.00 – 14.05: Introduction from One Nucleus and Domainex
14.05 – 14.45: Presentation from Andrew Ratcliffe, Head of Chemistry and Scott Martin, Head of the Bioanalytical Sciences Department, Domainex
14.45 – 15.00: Q&A and Close

Register now or contact One Nucleus:
Phone: 01223 896450
Phone: 01223 896456
Email: info@onenucleus.com
Email: accounts@onenucleus.com