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- ADME and Bioanalytical Sciences
- Analytical Chemistry
- Assay Development
- Biochemical Assays
- Biophysical Assays
- Cell Based Assays
- Computational Chemistry
- Fragment and Compound Screening
- Integrated Drug Discovery Services
- Medicinal Chemistry
- Protein Expression and Purification Services
- Structural Biology
- Synthetic Chemistry
- Virtual screening
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Research Phases
- Research Phases
- Hit Identification
- Hit to Lead
- Lead Optimisation
- Therapeutic Areas
- Target Classes
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- Approaches & Techniques
- CDH (Target Gene Fragmentation)
- Cryogenic Electron Microscopy (Cryo-EM)
- Differential Scanning Fluorimetry (DSF) and nanoDSF Services
- Direct-to-Biology (D2B)
- eProtein Discovery
- Flow Cytometry
- Fragment Based Drug Discovery (FBDD)
- FragmentBuilder
- Grating-Coupled Interferometry
- High Throughput Screening
- Isothermal Titration Calorimetry (ITC)
- LeadBuilder
- PoLiPa (Membrane Protein Solubilisation)
- Spectral Shift and MST Services
- Structure Based Drug Design (SBDD)
- Surface Plasmon Resonance (SPR)
- X-ray Crystallography
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ADME and Bioanalytical Sciences
Providing essential understanding of drug metabolism and interaction using bioanalytical expertise
Domainex offers you a comprehensive suite of assays that provide essential information on the absorption, distribution, metabolism and excretion of your novel compounds, determined via our suite of bioanalytical services.
ADME testing results can be used to predict how they will behave in the body, and to assess their potential for adverse interactions with other drugs. This valuable information is used by our medicinal chemists, combined with biological screening data, in order to select compounds for progression and to identify candidate drugs in the shortest time possible.
In Vitro ADME Assays
Our ADME services are provided to you as part of our integrated drug discovery services. We can provide a range of in vitro tests including:
- Physico-chemical property profiling:
- LogD and ChromLogD
- Solubility (kinetic and thermodynamic) in phosphate-buffered saline (PBS) and biological fluids, and at a range of pH values
- Stability in PBS or biological fluids (e.g. plasma, blood and cerebrospinal fluid)
- Metabolic stability (as % turnover, half-life or intrinsic clearance):
- Liver microsomes
- Cryopreserved hepatocytes
- Other tissues and fluids
- CYP450 inhibition
- hERG inhibition
- Glutathione (GSH) reactivity
- Plasma protein binding
- Plasma stability and blood stability
- Cell accumulation and permeability
- Permeability in a Caco-2 cell assay
- MDCK-MDR1
- PAMPA
- Tissue bioanalysis
- Metabolite identification (in liver microsomes and hepatocytes)
- Reactive metabolite screening
- Design of experimental formulations (for IV, PO, SC and IP dosing)
Pharmacokinetic Services
For the next stage of ADME assessment, we can arrange for your compounds to be tested by our research partners, in routine or customised pharmacokinetic assays. Domainex has built up excellent working relationships with a number of third party organisations, giving you a seamless solution for PK profiling during Lead Optimisation.
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