In vitro assays to model primary human T cell activation

T cells are a class of lymphocyte that are important in the adaptive immune response, providing protection against pathogens.

T Cell imges

At Domainex, we have established an in vitro primary human helper T cell services incorporating several T cell activation readouts. By stimulating helper T cells with antibodies, proliferation, cell clustering and secretion of a pro-inflammatory cytokine is increased. This effect can be modulated with a known phosphoinositide 3-kinase (PI3K) inhibitor.

 

T cell data